Two sample MR report
HLA-DRB1_Endothelial Cell (Endo) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 16 | -0.1049040 | 0.0451125 | 0.0355927 |
| Weighted median | 16 | 0.0390177 | 0.0123447 | 0.0015740 |
| Inverse variance weighted | 16 | 0.0207218 | 0.0086762 | 0.0169237 |
| Simple mode | 16 | 0.0445473 | 0.0239233 | 0.0822980 |
| Weighted mode | 16 | 0.0442844 | 0.0270379 | 0.1222519 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 9.209056 | 14 | 0.8174297 |
| Inverse variance weighted | 17.221871 | 15 | 0.3057749 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0555639 | 0.0196291 | 0.0133485 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002211 | 0 | TRUE | 0.1597734 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
